Nicholas O Davidson Selected Research

APOBEC-1 Deaminase

9/2010	APOBEC-1-mediated RNA editing.
6/2009	Decreased expression of cholesterol 7alpha-hydroxylase and altered bile acid metabolism in Apobec-1-/- mice lead to increased gallstone susceptibility.
9/2007	Deletion of the AU-rich RNA binding protein Apobec-1 reduces intestinal tumor burden in Apc(min) mice.
10/2004	Apobec-1 protects intestine from radiation injury through posttranscriptional regulation of cyclooxygenase-2 expression.
5/2002	Apobec-1 transcription in rat colon cancer: decreased apobec-1 protein production through alterations in polysome distribution and mRNA translation associated with upstream AUGs.
1/2002	C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme.

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Nicholas O Davidson Research Topics

Disease

12	Non-alcoholic Fatty Liver Disease 10/2022 - 04/2011
11	Inflammation (Inflammations) 01/2022 - 02/2011
11	Neoplasms (Cancer) 01/2021 - 01/2002
9	Fibrosis (Cirrhosis) 10/2022 - 04/2014
9	Obesity 01/2020 - 11/2006
7	Colonic Neoplasms (Colon Cancer) 01/2020 - 05/2002
7	Colorectal Neoplasms (Colorectal Cancer) 01/2016 - 04/2007
6	Hepatocellular Carcinoma (Hepatoma) 10/2015 - 04/2003
5	Adenoma (Adenomas) 01/2022 - 08/2006
5	Fatty Liver 02/2020 - 07/2005
5	Abetalipoproteinemia (Bassen Kornzweig Syndrome) 10/2019 - 02/2006
5	Gallstones (Gallstone) 01/2017 - 05/2009
5	Weight Gain 05/2014 - 11/2004
4	Liver Diseases (Liver Disease) 01/2022 - 03/2010
4	Insulin Resistance 04/2020 - 09/2006
4	Carcinogenesis 09/2014 - 05/2002
3	Sepsis (Septicemia) 01/2021 - 01/2012
3	Infections 01/2021 - 08/2004
3	Colitis 05/2014 - 02/2012
3	Hypobetalipoproteinemias (Hypobetalipoproteinemia) 07/2012 - 01/2004
2	Intestinal Failure 01/2022 - 01/2022
2	Short Bowel Syndrome 01/2022 - 01/2021
2	Diarrhea 05/2021 - 04/2020
2	Dysbiosis 01/2021 - 01/2019
2	Hypertension (High Blood Pressure) 01/2020 - 08/2006
2	Atherosclerosis 10/2015 - 07/2004
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 05/2014 - 04/2010
2	Type 2 Diabetes Mellitus (MODY) 12/2012 - 08/2006
2	Body Weight (Weight, Body) 04/2012 - 01/2008
2	Hypercholesterolemia 08/2006 - 07/2004
1	Cholestasis 01/2022
1	Maternal Obesity 01/2022
1	Alcoholic Fatty Liver 01/2022
1	Neuroendocrine Tumors (Neuroendocrine Tumor) 05/2021
1	Peptic Ulcer (Peptic Ulcers) 05/2021
1	Zollinger-Ellison Syndrome (Syndrome, Zollinger-Ellison) 05/2021
1	Pancreatitis 01/2021
1	Liver Neoplasms (Liver Cancer) 01/2021

Drug/Important Bio-Agent (IBA)

15	LipidsIBA 01/2022 - 11/2004
11	CholesterolIBA 01/2021 - 02/2006
10	Proteins (Proteins, Gene)FDA Link 10/2022 - 08/2005
8	Bile Acids and Salts (Bile Acids)IBA 01/2022 - 06/2009
8	Triglycerides (Triacylglycerol)IBA 01/2021 - 02/2003
8	O(4)-methylthymidine triphosphateIBA 01/2021 - 02/2006
8	microsomal triglyceride transfer proteinIBA 10/2019 - 11/2006
7	RNA (Ribonucleic Acid)IBA 01/2021 - 02/2003
7	ChylomicronsIBA 01/2021 - 05/2005
7	Messenger RNA (mRNA)IBA 02/2020 - 01/2002
6	FructoseIBA 01/2021 - 09/2006
6	APOBEC-1 DeaminaseIBA 09/2010 - 01/2002
5	EnzymesIBA 10/2022 - 04/2003
5	Fatty Acids (Saturated Fatty Acids)IBA 04/2020 - 04/2012
5	Fatty Acid-Binding ProteinsIBA 01/2017 - 11/2006
4	Lipoproteins (Lipoprotein)IBA 01/2022 - 07/2004
4	CytokinesIBA 01/2017 - 02/2011
4	ApolipoproteinsIBA 07/2005 - 02/2003
3	VLDL LipoproteinsIBA 01/2021 - 11/2006
3	Dietary Fats (Dietary Fat)IBA 01/2021 - 01/2013
3	Small Interfering RNA (siRNA)IBA 01/2020 - 08/2005
3	AcidsIBA 01/2017 - 01/2008
3	Carrier Proteins (Binding Protein)IBA 01/2017 - 01/2008
3	AzoxymethaneIBA 09/2014 - 04/2007
3	RNA-Binding Proteins (RNA-Binding Protein)IBA 09/2014 - 09/2007
3	Dextrans (Dextran)FDA Link 09/2014 - 04/2007
3	sodium sulfate (sodium bisulfate)FDA LinkGeneric 09/2014 - 04/2007
3	Apolipoproteins B (ApoB)IBA 07/2005 - 01/2004
2	Phospholipases (Phospholipase)IBA 10/2022 - 01/2020
2	Phospholipids (Phosphatides)FDA LinkGeneric 01/2022 - 03/2014
2	Protons (Proton)IBA 11/2020 - 12/2019
2	AcyltransferasesIBA 02/2020 - 01/2020
2	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 10/2019
2	Insulin (Novolin)FDA Link 01/2020 - 10/2019
2	Biomarkers (Surrogate Marker)IBA 01/2020 - 04/2011
2	Ethanol (Ethyl Alcohol)IBA 05/2015 - 05/2013
2	MicroRNAs (MicroRNA)IBA 08/2014 - 04/2011
2	Transcription Factors (Transcription Factor)IBA 04/2014 - 04/2007
2	Cytidine DeaminaseIBA 10/2012 - 06/2009
2	Cre recombinaseIBA 02/2012 - 04/2007
1	very low density lipoprotein triglycerideIBA 10/2022
1	3,5- diethoxycarbonyl- 1,4- dihydrocollidineIBA 01/2022
1	ursodoxicoltaurineIBA 01/2022
1	FatsIBA 01/2022
1	Transcription Factor CHOPIBA 01/2022
1	GastrinsIBA 05/2021
1	Choline (Choline Chloride)IBA 01/2021
1	Streptozocin (Streptozotocin)FDA Link 01/2021
1	JNK Mitogen-Activated Protein KinasesIBA 01/2021
1	NF-kappa B (NF-kB)IBA 01/2021
1	Methionine (L-Methionine)FDA Link 01/2021
1	TrypsinogenIBA 01/2021
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2021
1	Diethylnitrosamine (N-Nitrosodiethylamine)IBA 01/2021
1	Tamoxifen FDA LinkGeneric 01/2021
1	Type 4 Fibroblast Growth Factor ReceptorIBA 04/2020

Therapy/Procedure

3	Fat-Restricted Diet (Diet, Fat Restricted) 01/2022 - 11/2004
2	Therapeutics 01/2022 - 04/2020
2	Ligation 01/2019 - 12/2017
1	Parenteral Nutrition 01/2022
1	Organ Transplantation 01/2022
1	Surgical Instruments (Clip) 01/2021